High Grade Cervical Squamous Intraepithelial Neoplasia

**Semantic type:** Neoplastic Process

**Definition:** A precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium.

**Synonyms:** - HSIL of Cervix - High Grade Cervical Squamous Intraepithelial Lesion - High-Grade CIN - High-Grade Cervical SIL - High-Grade Cervical Squamous Intraepithelial Lesion