Tumor Necrosis Factor Signaling Process

**Semantic type:** Physiologic Function

**Definition:** Any process which promotes expression of tumor necrosis factors, their subsequent secretion, binding to cognate receptors and intracellular signaling, and results in promoting insulin resistance, fever and macrophage phagocytosis, stimulating the hypothalmic-pituitary-adrenal axis and acute phase responses, and suppressing appetite. This process is involved in coordinating systemic responses to pathogenic infection.

**Synonyms:** - Tumor Necrosis Factor Activation