Cyproterone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic steroidal anti-androgen with antineoplastic activity. Cyproterone, in its acetate form, binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progesterogenic activity, resulting in a reduction in testicular androgen secretion and total androgen blockade. (NCI04)

**Synonyms:** - CYPROTERONE - Med Cyproterone - SH-881