Negative Regulation of Lymphocyte Activation

**Semantic type:** Physiologic Function

**Definition:** Lymphocyte Suppression involves interference with, or restraint of, the production and activity of lymphocytes. Formed in lymphoid tissue, lymphocytes are white blood cells that can generally be classified as either T- or B-cells. T-lymphocytes provide cell-mediated immunity, while B-lymphocytes produce antibodies that provide humoral immunity. Suppression decreases the ability of lymphocytes to mount an immune response to invading substances.

**Synonyms:** - Lymphocyte Suppression