Dapsone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.

**Synonyms:** - 1358F - 1358F - 4,4'-Sulfonylbis[benzenamine] - 4,4'-Sulfonylbisbenzamine - 4,4'-Sulfonylbisbenzeneamine - 4,4'-Sulfonyldianiline - 4,4'-Sulfonyldianiline - Aczone - Avlosulfon - Avlosulfon - Bis(4-aminophenyl) sulfone - Bis(4-aminophenyl)sulfone - Croysulfone - Croysulfone - DADPS - DADPS - DAPSONE - DDS - Diphenasone - Diphenasone - Disulone - Disulone - Dumitone - Dumitone - Eporal - Eporal - Novophone - Novophone - Sulfona-MAE - Sulfona-Mae - Sulphadione - Undolac - dapsone