Atypical Fibroxanthoma

**Semantic type:** Neoplastic Process

**Definition:** An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, usually affecting the actinic-damaged skin of the elderly. The tumor presents as a single cutaneous nodule which is often ulcerated. Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. The vast majority of patients have an excellent prognosis following conservative therapy. Recurrences are infrequent, and metastasis is rare.

**Synonyms:** - AFX - Atypical Cutaneous Fibroxanthoma - Atypical Fibrous Histiocytoma - Atypical Fibroxanthoma of Skin - Atypical Fibroxanthoma of the Skin - Atypical Skin Fibroxanthoma - Atypical fibrous histiocytoma - Atypical fibroxanthoma - Malignant Fibrous Histiocytoma of Skin - Skin Malignant Fibrous Histiocytoma - Superficial Malignant Fibrous Histiocytoma