Diazooxonorleucine

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** An L-glutamine diazo analogue amino acid antibiotic isolated from a species of the bacterial genus Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways involved in the syntheses of D-glucosamine phosphate, purines and pyrimidines. This agent inhibits phosphate-activated glutaminase, a key enzyme for the synthesis of releasable glutamine, depleting cells of this essential amino acid and reducing their capacity to proliferate.

**Synonyms:** - 6-DIAZO-5-OXO-L-NORLEUCINE - 6-DIAZO-5-OXO-L-NORLEUCINE - 6-diazo-5-oxo-L-norleucine - 6-diazo-5-oxo-norleucine - DON