Hereditary Gastric Diffuse Adenocarcinoma

**Semantic type:** Neoplastic Process

**Definition:** An autosomal dominant inherited adenocarcinoma that arises from the gastric mucosa and is caused by CDH1 and rarely CTNNA1 gene mutations. It is characterized by the presence of poorly cohesive malignant cells and absence of glandular formations.

**Synonyms:** - Hereditary Diffuse Gastric Adenocarcinoma - Hereditary Diffuse Gastric Cancer