Blue Rubber Bleb Nevus Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A rare congenital disorder that is caused by somatic TEK gene mutations and presents with multifocal venous malformations (blebs) on the skin, gastrointestinal tract, and soft tissues. Patients develop anemia due to chronic gastrointestinal bleeding that requires lifelong treatment with iron and blood transfusions.

**Synonyms:** - BRBNS - Bean Syndrome