Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** An aggressive, epidermotropic primary cutaneous T-cell lymphoma composed of small to medium-sized, or medium-sized to large, CD8-positive T-lymphocytes with pleomorphic or blastic nuclei. Epidermotropism is often pronounced, and angiocentricity and angioinvasion may be present. It manifests with localized or disseminated eruptive papules and nodules or tumors.

**Synonyms:** - PCAETL - Primary Cutaneous Aggressive Epidermotropic CD8-Positive T-Cell Lymphoma - Primary Cutaneous CD8-Positive Aggressive Epidermotropic T-Cell Lymphoma - Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma