Oncogene MCF2

**Semantic type:** Gene or Genome

**Definition:** Human Oncogene MCF2 is a mutated variant of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at 15q15-q23. Oncogene MCF2 disrupts normal cell function.

**Synonyms:** - DBL - Diffuse B-Cell Lymphoma Oncogene - MCF.2 Cell Line Derived Transforming Sequence - MCF2