Recombinant Human Endostatin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant human proteolytic fragment of the C-terminal end of type XVIII collagen. Endostatin induces microvascular endothelial cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may result in a reduction in tumor burden. This agent also may decrease hepatic metastasis by inhibiting proinflammatory cytokines and vascular cell adhesion molecule (VCAM)-dependent cell attachment to the hepatic microvasculature. (NCI04)

**Synonyms:** - ENDOSTATIN - Endostar - Endostatin - Endostatin - N-Terminal-MGGSHHHHH-Endostatin (Human Recombinant) - Recombinant Endostatin - endostatin - rhEndostatin