Frameshift Mutation Abnormality

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** Insertion or deletion of one, two or four nucleotides that alters the correct reading frame of an amino acid-coding DNA sequence, resulting in an amino acid sequence that is changed or truncated. Frame shift mutations typically result in a mutated protein product that is inactive. This type of mutation abnormality can be either inherited or somatic.

**Synonyms:** - Frameshift - Frameshift Mutation