Nucleotide Transversion Abnormality

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A point mutation that involves the substitution of a pyrimidine base for a purine base or substitution of a purine base for a pyrimidine base. Nucleotide transversions change the purine-pyrimidine orientation of a DNA sequence. A nucleotide transversion abnormality may be heritable or occur somatically.

**Synonyms:** - Transversion - Transversion Mutation