CYP2C19*3 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2C19*3 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type allele, encodes cytochrome P450 2C19*3 protein. The CYP2C19*3 allele exhibits a clinically-relevant SNP (c.636G>A) in exon 3 that results in a W212X coding change. This alteration in protein sequence abolishes the enzymatic activity of the cytochrome P450 2C19*3 protein.

**Synonyms:** - CYP2C19*3 - CYP2C19, W212X - CYP2C19, c.636G>A - CYP2C19, m2 - Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*3 Allele