CYP2C19*5 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2C19*5 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type allele, encodes cytochrome P450 2C19*5 protein. The CYP2C19*5 allele exhibits a clinically-relevant SNP (c.1297C>T) in exon 9 that results in a R433W coding change in the heme-binding region of the protein. This alteration in protein sequence abolishes the enzymatic activity of the cytochrome P450 2C19*5 protein.

**Synonyms:** - CYP2C19*5 - CYP2C19, R433W - CYP2C19, c.1297C>T - CYP2C19, m4 - Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*5 Allele