CYP2D6*8 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2D6*8 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*8 protein. The CYP2D6*8 allele exhibits a clinically-relevant SNP (g.1758G>T) in exon 3 that generates a stop codon. This alteration yields a truncated cytochrome P450 2D6*8 protein that is enzymatically inactive.

**Synonyms:** - CYP2D6*8 - CYP2D6, g.1758G>T - CYP2D6G - Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*8 Allele