ABCB1 1 Allele

**Semantic type:** Gene or Genome

**Definition:** Human ABCB1-C allele is the wild-type form of the human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) gene (ABC gene family), located at located at 7q21.1, which encodes multidrug resistance protein 1. Amplification of the ABCB1 gene is a major determinant in the development of multi-drug resistance which decreases the effectiveness of many chemotherapeutic agents used in cancer treatment.

**Synonyms:** - ABCB1-C - ABCB1-C Allele - MDR1-C - MDR1-C Allele - P-Glycoprotein Transporter C Allele