TPMT wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TPMT wild-type allele is located in the vicinity of 6p22.3 and is approximately 26 kb in length. This allele, which encodes thiopurine S-methyltransferase protein, is involved in the S-methylation of thiopurine drugs. Certain allelic variants of the TPMT gene are associated with either decreased gene expression or reduced enzymatic activity of their corresponding protein products.

**Synonyms:** - TPMT Wild-type Allele - TPMT*1 - TPMT*1 Allele - TPMT, Wild-type - Thiopurine S-Methyltransferase wt Allele