Doxycycline

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline binds to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.

**Synonyms:** - DOXYCYCLINE - Doxycycline Monohydrate - doxycycline