CYP2C19*12 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2C19*12 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type allele, encodes cytochrome P450 2C19*12 protein. The CYP2C19*12 allele exhibits a clinically-relevant SNP (c.1473A>C) in exon 9 that results in a X491C coding change. This alteration yields an unstable cytochrome P450 2C19*12 protein that is predicted to have an additional 26 amino acids.

**Synonyms:** - CYP2C19*12 - CYP2C19, X491C - CYP2C19, c.1473A>C - Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*12 Allele