CYP3A5*3 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP3A5*3 allele is located in the vicinity of 7q21.1 and is approximately 32 kb in length. This allele, a variant form of the human CYP3A5 wild-type allele, encodes cytochrome P450 3A5*3 protein. The CYP3A5*3 allele exhibits a clinically-relevant SNP (g.6986A>G) in intron 3 that results in a splicing defect and premature stop at 102 amino acids. This alteration severely decreases the enzymatic activity of the cytochrome P450 3A5*3 protein.

**Synonyms:** - CYP3A5*3 - CYP3A5, g.6986A>G - Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*3 Allele