CYP3A5*8 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP3A5*8 allele is located in the vicinity of 7q21.1 and is approximately 32 kb in length. This allele, a variant form of the human CYP3A5 wild-type allele, encodes cytochrome P450 3A5*8 protein. The CYP3A5*8 allele exhibits a clinically-relevant SNP (g.3699C>T) in exon 2 that results in a R28C coding change. This alteration in protein sequence decreases the enzymatic activity of the cytochrome P450 3A5*8 protein.

**Synonyms:** - CYP3A5*8 - CYP3A5, R28C - CYP3A5, g.3699C>T - Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*8 Allele