CYP3A5*10 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP3A5*10 allele is located in the vicinity of 7q21.1 and is approximately 32 kb in length. This allele, a variant form of the human CYP3A5 wild-type allele, encodes cytochrome P450 3A5*10 protein. This allele exhibits a clinically-relevant SNP (g.6986A>G) in exon 10 that causes a splicing defect. The resulting alteration in protein sequence almost completely abolishes the enzymatic activity of the cytochrome P450 3A5*10 protein.

**Synonyms:** - CYP3A5*10 - CYP3A5, g.6986A>G - Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*10 Allele