CYP3A4*17 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP3A4*17 allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, a variant form of the CYP3A4 wild-type allele, encodes cytochrome P450 3A4*17 protein. The CYP3A4*17 allele exhibits a clinically-relevant SNP (g.15615T>C) in exon 7 that results in a F189S coding change. This alteration in protein sequence severely decreases the enzymatic activity of the cytochrome P450 3A4*17 protein.

**Synonyms:** - CYP3A4*17 - CYP3A4, F189S - CYP3A4, g.15615T>C - Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*17 Allele