CYP2C8*2 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2C8*2 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*2 protein. The CYP2C8*2 allele exhibits a clinically-relevant SNP (c.805A>T) in exon 5 that results in an I269F coding change. This sequence alteration in the cytochrome P450 2C8*2 protein increases the Km of this enzyme for paclitaxel, thereby decreasing the clearance of this drug.

**Synonyms:** - CYP2C8*2 - CYP2C8, I269F - CYP2C8, c.805A>T - Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*2 Allele