CYP2C8*3 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2C8*3 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*3 protein. The CYP2C8*3 allele exhibits clinically-relevant SNPs (c.416G>A, c.1196A>G) in exons 3 and 8 that result in coding changes (R139K, K399R). These alterations in protein sequence severely decrease the enzymatic activity of the cytochrome P450 2C8*3 protein.

**Synonyms:** - CYP2C8*3 - CYP2C8, R139K, K399R - CYP2C8, c.416G>A, c.1196A>G - Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*3 Allele