CYP2C8*7 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2C8*7 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*7 protein. The CYP2C8*7 allele exhibits a clinically-relevant SNP (c.556C>T) in exon 4 that results in a R186X coding change. This alteration yields a truncated cytochrome P450 2C8*7 protein that is enzymatically inactive.

**Synonyms:** - CYP2C8*7 - CYP2C8, R186X - CYP2C8, c.556C>T - Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*7 Allele