CYP1A2*11 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP1A2*11 allele is located within 15q24 and is approximately 8 kb in length. This allele, a variant form of the CYP1A2 wild-type allele, encodes cytochrome P450 1A2*11 protein. The CYP1A2*11 allele exhibits a clinically-relevant SNP (g.558C>A) in exon 2 that results in a F186L coding change. This alteration in protein sequence severely decreases the enzymatic activity of the cytochrome P450 1A2*11 protein.

**Synonyms:** - CYP1A2*11 - CYP1A2, F186L - CYP1A2, g.558C>A - Cytochrome P450, Family 1, Subfamily A, Polypeptide 2*11 Allele