CYP2D6*2 Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYP2D6*2 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*2 protein. The majority of haplotypes of the CYP2D6*2 allele exhibit SNPs (g.2850C>T; g.4180G>C) in exons 6 and 9 that result in R296C and S486T coding changes. These alterations in protein sequence have no significant effect on the enzymatic activity of the cytochrome P450 2D6*2 protein.

**Synonyms:** - CYP2D6 NG_008376.4:g.[7870C>T;9200G>C] - CYP2D6*2 - CYP2D6, R296C, S486T - CYP2D6L - Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*2 Allele