Amsterdam Criteria

**Semantic type:** Clinical Attribute

**Definition:** Research criteria established for defining Hereditary Non-Polyposis Colorectal Cancer (HNPCC) families as established by the International Collaborative Group (ICG) meeting in Amsterdam in 1990: 1. One member diagnosed with colorectal cancer before age 50; 2. Two affected generations; 3. Three affected relatives, 1 of them a first-degree relative of the other 2; 4. Familial adenomatous polyposis should be excluded; 5. Tumors should be verified by pathological examination.

**Synonyms:** - Amsterdam Criteria I