Splenic Marginal Zone Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** A B-cell non-Hodgkin lymphoma composed of small lymphocytes which surround and replace the splenic white pulp germinal centers. It involves the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood. When lymphoma cells are present in the peripheral blood, they are usually, but not always, characterized by the presence of short polar villi. (WHO)

**Synonyms:** - Marginal Zone Lymphoma of Spleen - Marginal Zone Lymphoma of the Spleen - SLVL - SMZL - Splenic Lymphoma with Circulating Villous Lymphocytes - Splenic Marginal Zone B-Cell Lymphoma - Splenic Marginal Zone B-Cell Lymphoma with Villous Lymphocytes - Splenic Marginal Zone Lymphoma with Villous Lymphocytes - Splenic marginal zone B-cell lymphoma - Splenic marginal zone lymphoma, NOS