Leukocyte Adhesion Deficiency Type 2

**Semantic type:** Disease or Syndrome

**Definition:** Leukocyte Adhesion Deficiency, Type II. An inherited disease affecting the metabolism of fucose, which affects the expression of the sialyl Lewis X antigen, the fucose-containing ligand for E- and P-selectins, resulting in a deficiency in neutrophil adhesion. SYN Sialyl-Lewis X defect.

**Synonyms:** - CDGIIc - Congenital Disorder of Glycosylation Type IIc - LAD-Type II - Sialyl-Lewis X Defect