Nijmegen Breakage Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** A disorder, wherein unstable chromosomes have a tendency to break and become rearranged, characterized by microcephaly, stunted growth, subnormal mental development, cafe-au-lait spots, and immunodeficiency. The syndrome is named after the University of Nijmegen in the Netherlands. (JABL99)

**Synonyms:** - NBS