Post-Transplant Lymphoproliferative Disorder

**Semantic type:** Disease or Syndrome

**Definition:** Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001)

**Synonyms:** - PTLD - PTLD - PTLD, NOS - Post transplant lymphoproliferative disorder, NOS - Post-transplant Lymphoproliferative Disorder - Post-transplant lymphoproliferative disorder (PTLD) - post-transplant lymphoproliferative disorder