Anisindione

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic indanedione anticoagulant. Anisindione interferes with the vitamin K-dependent hepatic synthesis of active clotting factors by inhibiting the reduction of vitamin K. This leads to an inhibition of gamma-carboxylation of glutamic acid residues to gamma-carboxyglutamic acid in clotting factors II, VII, IX and X. The consequential effects of this inhibition include a reduced activity of these clotting factors and prolonged blood clotting time.

**Synonyms:** - 1,3-Indandione, 2-(p-methoxyphenyl)- - 2-p-Anisyl-1,3-indandione - ANISINDIONE - Miradon - Unidone