Cloxacillin Sodium

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** The sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.

**Synonyms:** - 3-o-Chlorophenyl-5-methyl-4-isoxazolylpenicillin Sodium - 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, Monosodium Salt,(2S,5R,6R)- - CLOXACILLIN SODIUM - Cloxapen - Orbenin - Tegopen