Dexchlorpheniramine Maleate

**Semantic type:** Pharmacologic Substance

**Definition:** The maleate salt form of dexchlorpheniramine, an alkylamine, and first-generation histamine antagonist with anti-allergic activity. Dexchlorpheniramine maleate competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.

**Synonyms:** - (+)-2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate(1:1) - (gamma-(4-Chlorophenyl)-pyridine-2-propyl)(dimethyl)ammonium hydrogen(Z)-maleate - DEXCHLORPHENIRAMINE MALEATE - Mylaramine - Polaramine - S-(+)-Chlorpheniramine Maleate - d-Chlorpheniramine Maleate