Dihydroergotamine Mesylate

**Semantic type:** Pharmacologic Substance

**Definition:** An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release.

**Synonyms:** - 9,10-Dihydroergotamine Mesylate - DIHYDROERGOTAMINE MESYLATE - Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,(5'alpha)-, monomethanesulfonate(salt) - Migranal