Fosfomycin Tromethamine

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** The tromethamine salt form of fosfomycin, a synthetic broad-spectrum antibiotic. Fosfomycin tromethamine binds to and inactivates the enzyme enolpyruvyl transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis. In addition, fosfomycin tromethamine reduces the adherence of bacteria to uroepithelial cells. (NCI05)

**Synonyms:** - (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1) - FOSFOMYCIN TROMETHAMINE - Fosfomycin Trometamol Salt - Fosfomycin compound with Trometamol - Monurol