Guanfacine Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of guanfacine, a centrally acting alpha-2 adrenergic agonist with antihypertensive activity. Alpha-2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. This leads to a decrease in heart rate and peripheral vascular resistance. (NCI05)

**Synonyms:** - Estulic - GUANFACINE HYDROCHLORIDE - N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride - Tenex