Ketoprofen

**Semantic type:** Pharmacologic Substance

**Definition:** A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

**Synonyms:** - Benzeneacetic Acid, 3-benzoyl-alpha-methyl- - Capisten - KETOPROFEN - Orudis - Oruvail - Propionic Acid, 2-(3-benzoylphenyl)-