Metaproterenol Sulfate

**Semantic type:** Pharmacologic Substance

**Definition:** The sulfate salt form of metaproterenol, a short-acting and selective sympathomimetic beta-receptor agonist with bronchodilator activity. Metaproterenol sulfate binds beta-2 adrenergic receptors in bronchial smooth muscle and stimulates intracellular adenyl cyclase, thereby increasing the production of cyclic adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, improve mucocliary clearance and reduce inflammatory cell mediator release, especially from mast cells.

**Synonyms:** - 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, Sulfate(2:1)(Salt) - 3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzyl Alcohol Sulfate - Alupent - METAPROTERENOL SULFATE - Novasmasol