Nalbuphine Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of nalbuphine, a synthetic phenanthrene opioid with opiate agonist and antagonist effects, used to treat moderate to severe pain and provide preoperative and postoperative analgesia and sedation. Nalbuphine hydrochloride binds to kappa-, mu- and delta-opioid receptors but not to sigma-opioid receptors. This opioid exerts its analgesic actions primarily through kappa-opioid-receptor agonism and partially through mu-opioid receptor agonism.

**Synonyms:** - (5alpha,6alpha)-17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol Hydrochloride - N-Cyclobutylmethyl-14-hydroxydihydronormorphine Hydrochloride - NALBUPHINE HYDROCHLORIDE - Nubain