Oxcarbazepine

**Semantic type:** Pharmacologic Substance

**Definition:** A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.

**Synonyms:** - 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide - OXCARBAZEPINE - Trileptal