Pemoline

**Semantic type:** Pharmacologic Substance

**Definition:** An oxazolidine compound with central nervous system (CNS) stimulant property. Although pemoline has pharmacological activity similar to other CNS stimulants, the exact mechanism and site of action are unknown. This agent has minimal sympathomimetic properties, but animal studies indicate it may work through dopaminergic mechanisms. Pemoline has been withdrawn from the U.S. market because of the agent's association with life threatening hepatic failure.

**Synonyms:** - 2-Imino-4-keto-5-phenyltetrahydrooxazole - 4(5H)-Oxazolone, 2-amino-5-phenyl- - 5-Phenylisohydantion - Cylert - PEMOLINE