Piperazine Citrate

**Semantic type:** Pharmacologic Substance

**Definition:** The citrate salt of piperazine, a cyclic amine with anthelminthic property. Piperazine citrate is a gamma-aminobutyric acid GABA receptor agonist and blocks the activity of acetylcholine at the neuromuscular junction thereby altering neuronal cell membrane permeability and causing hyperpolarization. This results in flaccid paralysis of worm musculature allowing the worm to become dislodged by peristalsis and expelled from the body.

**Synonyms:** - Antepar - PIPERAZINE CITRATE - Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate(3:2) - Pipralen - Pripsen