Pramocaine Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property. Pramocaine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.

**Synonyms:** - 4-(3-(p-Butoxyphenoxy)propyl)morpholine Hydrochloride - Fleet - PRAMOXINE HYDROCHLORIDE - Pramoxine Hydrochloride - Tronolane - Tronothane