Prilocaine

**Semantic type:** Pharmacologic Substance

**Definition:** A toluidine derivative and intermediate-acting amino amide with local anesthetic property. Prilocaine stabilizes the neuronal membrane by preferential binding to and inhibiting depolarization of the voltage-gated sodium channel. This results in a decrease in membrane permeability and subsequent inhibition of the ionic sodium influx required for the initiation and conduction of impulses.

**Synonyms:** - 6,7-Epoxytropine Tropate - PRILOCAINE - Propanamide, N-(2-methylphenyl)-2-(propylamino)-(9CI) - Propitocaine - o-Methyl-alpha-propylaminopropionanilide - o-Propionotoluidide, 2-(propylamino)-