Sulfanilamide

**Semantic type:** Pharmacologic Substance

**Definition:** An organic sulfur compound structurally similar to p-aminobenzoic acid (PABA) with antibacterial property. Sulfanilamide competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.

**Synonyms:** - 4-Aminobenzenesulfonamide - 4-Sulfamoylaniline - AVC - SULFANILAMIDE - Sultrin - Trysul